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KMID : 0370220170610040210
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Yakhak Hoeji
2017 Volume.61 No. 4 p.210 ~ p.215
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Immunoadjuvant Efficacy of Ginsenoside RK1 against Disseminated Candidiasis
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Han Yong-Moon
Rhew Zheong-Imm
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Abstract
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We have previously shown that the antibody, specific for β-1,2 mannotriose on the Candida albicans cell wall (CACW), is protective against disseminated candidiasis and vaginal infection. Nevertheless, the isolation of such epitope requires tremendous amount of time, which is very costly. This led us to find a simple way to obtain an immuoadjuvant capable of inducing protective antibodies. Thus, in the present study, for the discovery of such adjuvant, we examined ginsenoside RK1 against Candida albicans-caused infections. Our data displayed that a formulae of CACW (C. albicans cell wall) combined with RK1 [CACW/RK1] enhanced production of anti-C. albicans antibody in mice. Analyses by IgG-isotyping showed that the formulae suppressed IgG1 (Th2-immune polarized) but enhanced IgG2a (Th1-immune polarized), thus resulting in a Th1 immunity. This effectiveness of RK1 was assessed in the murine model of disseminated candidiasis caused by C. albicans. The assessment indicated that the formulae with RK1 enhanced resistance of mice against the candidiasis, whereas [CACW] alone was not protective. Overall, RK1 has immunoregulatory activity that provokes the production of protective antibody in mice through enhancing Th1 immunity.
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KEYWORD
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ginsenoside RK1, immunoadjuvant, Th1/Th2, Candida albicans, disseminated candidiasis
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